Table 2.

MBD2 expression and effects on respiratory outcomes.

MBD2	Effects	Respiratory outcome	References
↑ MBD2	↓ Treg function by Foxp3 demethylation	Asthma	[137]
	↑ IL-17 expression	Th17 severe asthma	[138]
	↓SOCS3	Th17 asthma	[140]
	↓ Treg functions	Severe asthma	[141]
	↑ HIF-1α	Th17 asthma	[143]
↓ MBD2	↑Th2 polarization	Asthma	[7]
	↑IL-4, IFN-γ	Asthma	[7]
	TGF-β1 attenuation	↓ airway remodeling, ↓ M2 macrophage gathering	[144]
MBD2-/-	Unsuppressed Tbet/Hlx axis	↓ Th17 differentiation	[136]