TABLE 3.
Association of IL-1B(3954)-SNP and the detection of periodontal pathogens and IL-1β levels in GCF on a site-level and subject-level analysis
| Variable | Site-level analysis (Periodontitis sites) |
Subject-level analysis (Healthy and Periodontitis sites) |
|||||
|---|---|---|---|---|---|---|---|
|
IL-1B(3954)-SNP Negative (n = 19) |
IL-1B(3954)-SNPPositive (n = 13) |
P-value |
IL-1B(3954)-SNP Negative (n = 19 pairs) |
IL-1B(3954)-SNP Positive (n = 13pairs) |
P-value | ||
| IL-1β Amount (pg) | Mean (SD) | 45.47 (33.60) | 134.6 (127.8) | <.01 | 31.81 (30.41) | 78.36 (106.3) | .058 |
| Median [Min-Max] | 47.28 [3.21, 146.49] | 81.69 [32.93, 450.17] | 20.41 [1.17, 146.49] | 42.56 [1.16, 450.17] | |||
| IL-1β Concentration (pg/μl) | Mean (SD) | 36.37 (26.88) | 113.0 (101.6) | <.01a,* | 44.57 (57.89) | 100.9 (104.5) | .013 |
| Median [Min-Max] | 37.82 [2.56, 117.19] | 85.03 [26.34, 360.13] | 31.86 [1.15, 352.41] | 52.03 [6.08, 369.38] | |||
| A.actinomycetemcomitans | Count (%) | 6 (31.58) | 4 (30.77) | 1.00d | 9 (23.68) | 4 (15.38) | .525e |
| F.nucleatum | Count (%) | 6 (31.58) | 9 (69.23) | .036 | 6 (15.79) | 13 (50.00) | <.01 |
| P.gingivalis | Count (%) | 9 (47.37) | 9 (69.23) | .221e | 10(26.32) | 13 (50.00) | .082e |
| T.forsythia | Count (%) | 19 (100) | 13 (100) | 1.00d | 28 (73.38) | 25 (96.15) | .052e |
| T.denticola | Count (%) | 11 (57.89) | 9 (69.23) | .713d | 13 (34.21) | 11 (42.31) | .516e |
Abbreviations: A.a: Aggregatibacter actinomycetemcomitans; F.n: Fusobacterium nucleatum; P.g: Porphyromonas gingivalis; T.d: Treponema Denticola; T.f: Tannerella forsythia.
a
Linear regression.
b
Mixed-effect regression model with random intercept.
c
Chi-square test.
d
Fisher exact test.
e
Mixed-effect logistic regression with random intercept.
*
Statistical significant difference (P < .05).