Table 3.

Tryptophan and tyrosine metabolism, Pentose metabolism, TCA cycle, and bile acid changes induced by inulin. A table showcasing the metabolite changes in tryptophan and tyrosine metabolism, pentose metabolism, TCA cycle, and bile acid metabolism due to the prebiotic inulin and differences and differences between E3FAD and E4FAD mice in the blood. Welch’s two-sample t-test was performed. Heat map of statistically significant biochemicals profiled when comparing groups are labeled as follows: Red and green shaded cells indicate p ≤ 0.05 (red specifies that the mean values are significantly higher for that comparison; green values significantly lower).

		Fold Change
		Inulin Ctrl
Pathway	Biochemical Name	E3FAD	E4FAD
Tryptophan Metabolism	indoleacrylate	2.91	5.68
	indolepropionate	6.42	9.68
	serotonin	1.37	1.29
	indoleacetylglycine	1.55	0.65
	N-acetyltryptophan	1.3	0.81
Tyrosine Metabolism	phenol sulfate	0.23	0.87
	phenol glucuronide	0.21	2.11
	p-cresol glucuronide	0.08	0.14
Pentose Metabolism	ribose	1.67	1.41
	ribitol	0.99	2.01
	ribonate	1.46	2.08
	ribulose/xylulose	1	1.37
	arabitol/xylitol	0.87	2.67
	arabonate/xylonate	1.22	1.36
	sedoheptulose	0.82	1.68
TCA Cycle	isocitric lactone	1.28	1.73
	alpha-ketoglutarate	1.73	2.53
	succinate	1.03	2
	fumarate	1.23	1.6
	malate	1.24	1.44
Primary Bile Acid Metabolism	cholate	1.06	10.92
	beta-muricholate	1.82	16.81
Secondary Bile Acid Metabolism	deoxycholate	0.8	8.78
	ursodeoxycholate	1.37	82.41
	7-ketodeoxycholate	0.86	82.44
	ursocholate	1.76	22.69