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. 2022 Jan 6;28(1):125–135. doi: 10.1038/s41591-021-01581-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, Swimmer plot by patient and tumor type. b, Kaplan-Meier (KM) estimates of overall survival for all patients (c) KM estimates of overall survival as per tumor type. Median survival for CNS tumors was 21.6 months. Median survival was not reached for non-CNS solid tumors. Two-sided log-rank test p-value is shown. d, KM estimates of progression free and overall survival for CNS tumors continuing ICI therapy. Note: prolonged median survival at 24 months (estimated 3 year OS = 49.1%) despite initial radiological progression at a median of 9.9 months (estimated 3 year PFS = 32%). Two-sided log-rank test p-value is shown.