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. 2022 Jan 6;28(1):125–135. doi: 10.1038/s41591-021-01581-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, Response and overall survival (OS) by single nucleotide variants (SNVs) per Mb. For survival analysis, median SNV burden was used. b, SNVs as a function of MMRD (blue) and MMRD + PPD (orange) status (left), and response association with both SNV and replication-repair deficiency status. c, Response and overall survival (OS) by microsatellite indels (MS-indels). For survival analysis, median MS-indel values were used. d, Response and overall survival by total MS-indel count for MMRD + PPD and MMRD-only cancers separately. e, Kaplan-Meier (KM) estimates using combined SNVs/Mb and MS-indel in all replication repair-deficiency cancers. For all box-plots for responders and non-responders, data are represented as median + /- interquartile range. For statistical significance in comparing responders and non-responders, the Wilcoxon-Mann-Whitney test was used. Survival analysis was performed using the Kaplan-Meier method, and the log-rank test was used to compare groups. All p values are 2-sided. (MMRD: mismatch repair deficiency; PPD: polymerase proofreading deficiency; MS-indel: microsatellite insertion/ deletion).