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. 2022 Jan 6;28(1):125–135. doi: 10.1038/s41591-021-01581-6

Extended Data Fig. 1. Genomic biomarkers (SNVs), survival and response to PD-1 blockade.

Extended Data Fig. 1

Response and overall survival by (a) total synonymous variants, (b) non-synonymous variants, (c) total indels, (d) total mutations/Mb, and (e) neoantigens. For survival, median values were utilized to stratify into ‘high’ and ‘low’ groups. For all box-plots for responders and non-responders, data are represented as median ± interquartile range. For statistical significance in comparing responders and non-responders, the Wilcoxon-Mann-Whitney test was used. Survival analysis was performed using the Kaplan-Meier method, and the log-rank test was used to compare groups. All p values are 2-sided.