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. 2022 Jan 29;149(4):1242–1252.e12. doi: 10.1016/j.jaci.2022.01.013

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© 2022 The Authors

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Fig 4 — SARS-CoV-2 NT50 analysis using serum samples from fully vaccinated mRNA-1273 (n = 23) individuals against SARS-CoV-2 WT, Alpha, Alpha-E484K, Beta, and Delta variants. A, Percentages of vaccinees who tested positive, borderline, or negative for half-maximum neutralization against SARS-CoV-2 WT and variants. B, Neutralization curves of mRNA-1273 immunized participants including highlighted median neutralization curves for WT and each variant. C, Individual NT50 serum dilutions for all tested SARS-CoV-2 viruses. Statistical significance between WT and variants was determined by Mann-Whitney U test for nonparametric distribution (∗P < .05; ∗∗P < .01). Medians are visualized as red lines together with the interquartile range as error bars. The cutoff value is illustrated by a gray dashed line.D, Determination of NT50 fold changes of SARS-CoV-2 variants relative to WT.