Table 3.
Patients within dataset of specific conditions previously associated with narcolepsy: control subjects versus subjects with narcolepsy [22]
| CCS category or ICD-9 diagnosis code | Patients with comorbidity, n (%) | Excess prevalence | p valuea | Odds ratiob (95% CI) | |
|---|---|---|---|---|---|
| Control N = 46,559 |
Narcolepsy N = 9312 |
||||
| Anxiety disorders (651) | 5554 (11.9) | 2333 (25.1) | 13.2% | < 0.0001 | 2.5 (2.4, 2.7) |
| Diabetes (49, 50) | 8835 (19.0) | 2635 (28.3) | 9.3% | < 0.0001 | 1.8 (1.7, 1.8) |
| Headache/migraine (84) | 8424 (18.1) | 3548 (28.3) | 20% | < 0.0001 | 2.9 (2.8, 3.1) |
| Mood disorders (657) | 6407 (13.8) | 3525 (37.9) | 24.1% | < 0.0001 | 4.0 (3.8, 4.2) |
| Obesity (3.11.2) | 3933 (8.4) | 1609 (17.3) | 8.8% | < 0.0001 | 2.3 (2.2, 2.5) |
| Periodic limb movement disorder (327.51) | 2675 (5.8) | 369 (4.0) | 3.7% | < 0.0001 | 14.8 (12, 18.1) |
| Sleep apnea (327.20, 327.21, 327.23, 327.27, and 3327.29) | 2675 (5.8) | 4787 (51.4) | 45.6% | < 0.0001 | 18.7 (17.5, 20.0) |
| REM behavior disorder (327.42) | 5 (0) | 44 (0.5) | 0.5% | < 0.0001 | 44 (17.4, 111) |
| Restless leg syndrome (333.94) | 307 (0.7) | 517 (5.6) | 4.9% | < 0.0001 | 8.9 (7.7, 10.3) |
Reproduced with permission from Black et al. [22]
CCS Clinical Classification Software, REM rapid eye movement
aConditional chi-squared test; accounts for matching
bOdds ratios interpreted as narcolepsy versus control