Table 2.

Reproduced from Schumacher et al. Estimation of PrCa risk by PRS using 147 risk SNPs. Men categorised into PRS percentiles based on the cumulative score distributed among controls

Risk category percentile	Relative risk	95% CI
< 1	0.15	0.11–0.2
1–10	0.35	0.32–0.37
10–25	0.54	0.51–0.57
25–75	1 (Baseline)
75–90	1.74	1.67–1.82
90–99	2.69	2.55–2.82
≥ 99	5.71	5.04–6.48

Men in with a PRS in the highest percentile of risk (≥ 99%) have a RR of 5.71 compared to controls [59]

Reprinted by permission from Springer Nature: Nature Genetics. Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci, Schumacher et al. ©2018