Table 3.
Base Cox proportional hazard models for investigator-assessed PFS in all-comers and BCL-2-positive population
| Model | Parameter | β | SE | RSE (%) | p value |
|---|---|---|---|---|---|
| All-comers | |||||
| Base PFS-AUCss nominal model | AUCss nominal | − 0.00181 (μg × day/mL) | 0.37 | 20,359.24 | 0.79 |
| BCL-2-positive population | |||||
| Base PFS-AUCss nominal model | AUCss nominal | − 0.2108 (μg × day/mL) | 0.46 | 21,761 | 0.65 |
AUCss venetoclax individual predicted steady-state area under the curve following the cohort-assigned dose, BCL-2 B cell lymphoma 2 protein, HR hazard ratio computed as exp(β), HR95CI 95% confidence intervals on hazard ratio, PFS progression-free survival, RSE relative standard error of β estimate (%), SE standard error of β estimate