Fig. 5.

Comparison of multivariable model adjusted mean hypothyroidism-related costs in the 1-year follow-up period. Note: p ≤ 0.001 for all comparisons. Adjusted mean costs were calculated using a generalized linear model regression (gamma distribution with log link), which controlled for index levothyroxine type (Synthroid vs. generic levothyroxine), age, gender, insurance type, region, baseline Quan-Charlson Comorbidity Index, year of index date, baseline treating physician specialty (endocrinologist, PCP, others), baseline hypothyroidism-related comorbidities, and other baseline HCRU and costs (flag for hypothyroidism-related inpatient hospitalizations and pharmacy dispensing; all-cause outpatient, pharmacy and total costs; and hypothyroidism-related inpatient, ER, outpatient, and total costs)