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. 2022 Jan 28;12:1581. doi: 10.1038/s41598-022-05665-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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HYPERLINK "sps:id::fig1||locator::gr1||MediaObject::0" Fixel metrics. Diagrammatic illustrations for all fixel metrics investigated are shown. Starting from a healthy fibre bundle differing structural changes can appear that are reflected by specific metrics. A loss in intraaxonal volume in a voxel is indicated by a reduction in fibre density. A reduced fibre-bundle cross-section reflects macrostructural—i.e., above voxel level—tract diameter changes in the plane orthogonal to the fixel surveyed. Fibre density and cross-section represents the product of FD and FC and is thus sensitive to combined structural changes. This figure is modification from Fig. 1 of Raffelt et al. 2017 and was produced using inkscape (https://inkscape.org/).