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. 2022 Jan 28;12:1581. doi: 10.1038/s41598-022-05665-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Tract of interest analysis. Left: error plots showing mean fibre density and cross-section percentage changes of the group of higher CSVD burden (WMH-Q4) with respect to the mean of the lower CSVD burden group (WMH-Q1, at x = 0) and corresponding 95% confidence intervals. Colour denotes significant tracts. Right: significantly differing tracts coloured corresponding to the left panel. Tracts are visualised from different perspectives: looking from left (upper left), from anterior (upper right), from right (lower left) and from superior (lower right). AF arcuate fasciculus, ATR anterior thalamic radiation, CC corpus callosum, CG cingulum, CST corticospinal tract, IFO inferior frontooccipital fasciculus, ILF inferior longitudinal fasciculus, SLF superior longitudinal fasciculus, UF uncinate fasciculus. Figure was produced using ggplot2⁵⁰.