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. 2022 Jan 28;12:1581. doi: 10.1038/s41598-022-05665-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Tract-wise comparison of white matter hyperintensity loads. Mean WMH loads are depicted as dots and 95% confidence intervals as corresponding error bars. Intervals of the lower CSVD burden group (WMH-Q1) are coloured light blue. If significantly differing in terms of WMH load, intervals of the higher CSVD burden group (WMH-Q4) are coloured in dark blue and if not grey. AF arcuate fasciculus, ATR anterior thalamic radiation, CC corpus callosum, CG cingulum, CST corticospinal tract, IFO inferior frontooccipital fasciculus, ILF inferior longitudinal fasciculus, SLF superior longitudinal fasciculus, UF uncinate fasciculus, WMH white matter hyperintensity. Figure was produced using ggplot2⁵⁰.