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. 2022 Jan 28;12:1581. doi: 10.1038/s41598-022-05665-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Whole-brain clinical fixel-based analysis and TBSS. Fixels and voxels that show a significant linear relationship (FWE-corrected p < 0.05) between metrics and the difference of TMT-B and TMT-A (TMT-delta) are visualised on the population template. (a) the SLF showed a significant linear relationship between FD and TMT-delta. (b) the MD was significantly correlated with TMT-delta bilaterally in temporal areas traversed by the AF and ILF. AF arcuate fasciculus, FD fibre density, FC fibre-bundle cross-section, FDC Fibre density and cross-section, ILF inferior longitudinal fasciculus, MD mean diffusivity, TMT-delta difference of trail making test b and a. Figure was produced using inkscape and mrview from MRtrix3 (https://www.mrtrix.org/).