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. 2022 Jan 28;13(1):92. doi: 10.1038/s41419-022-04531-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A–C K562-R cells were infected with shUSP6-1 or shNC and overexpressed GLS1 (oeGLS1). A Western blot analysis of GLS1 expression. B Biochemical detection of glutamine uptake. C Flow cytometric detection of apoptosis treated by 1 μM IM or DMSO. K562 cells were infected with USP6 gene overexpression lentivirus (oeUSP6) or empty vector (Vector) and interfered with GLS1 (shGLS1). D, E Western blot analysis of GLS1 expression. F Biochemical detection of glutamine uptake. G, H Flow cytometric detection of apoptosis. *P < 0.05, **P < 0.01, ***P < 0.001.