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. 2022 Jan 28;8:40. doi: 10.1038/s41420-021-00763-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A RT-qPCR detected SP1 mRNA expression in cardiomyocytes; B ELISA detected CK-MB level in cardiomyocytes; C ELISA detected cTn-I level in cardiomyocytes; D ELISA detected TNF-α, IL-1β, and IL-6 levels in cardiomyocytes; E MDA level in cardiomyocytes; F SOD activity in cardiomyocytes; G and H Flow cytometry detected apoptosis of cardiomyocytes; I RT-qPCR detected Bax mRNA expression in cardiomyocytes; J RT-qPCR detected Bcl-2 mRNA expression in cardiomyocytes; K RT-qPCR detected HDAC4 mRNA expression in cardiomyocytes; L RT-qPCR detected HIF-1α mRNA expression in cardiomyocytes; M–N Western blot detected HDAC4 and HIF-1α protein expression in cardiomyocytes; O RT-qPCR detected miR-124-3p expression in cardiomyocytes; the measurement data were expressed as mean ± standard deviation, repetition = 3, *P < 0.05 compared with the LPS + si-NC group.