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. 2022 Jan 28;8:40. doi: 10.1038/s41420-021-00763-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A RT-qPCR detected SP1 mRNA expression after overexpression of miR-124-3p in LPS-induced cardiomyocytes; B and C Western blot detected SP1 protein expression level after overexpression of miR-124-3p; D Bioinformatics website predicted the binding site of miR-124-3p and SP1; E Dual luciferase reporter gene assay verified the regulatory relationship between miR-124-3p and SP1; F RIP assay verified the binding relationship between miR-124-3p and SP1; G RNA-pull down assay verified the binding relationship between miR-124-3p and SP1; H CO-IP assay detected the interaction between SP1 and HDAC4; the measurement data were expressed as mean ± standard deviation, repetition = 3, *P < 0.05 compared with the LPS + mimic NC group; ^*P < 0.05 compared with the mimic NC group; ^P < 0.05 compared with the Bio-NC group.