Fig. 4. Comparing lactation-derived mammary cell (LMC) luminal clusters (LCs) with all other non-lactating mammary cell (NMC) types reveals similarity to non-lactating luminal progenitor (LP) cells.
a Violin plots of the mammary cell scores for i hormone-responsive (HR, mature luminal), ii luminal progenitor (LP), iii stromal or iv myoepithelial cells across the major cell clusters identified in this study. b Differential gene expression analysis derived using quasi-likelihood negative binomial generalized log-linear models revealed 1146 genes highly expressed in LC LMCs compared to 922 genes more highly expressed in LP NMCs, as displayed by a volcano plot (for a full list, see Supplementary Dataset 7). c Important biological process gene ontology pathways that were annotated by the top 10% of genes significantly differentially expressed (false discovery rate corrected p value <1 × 10−8) and upregulated in either LC (left) or LP (right); for a full list, see Supplementary Dataset 8 and 9. d Key LP (left) or LC (right) genes expressed in NMC-LP, LMC-LC or all other NMC clusters; colours represent overall normalized gene expression and size equals cell proportions.