Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 28;12:1567. doi: 10.1038/s41598-022-05323-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Liraglutide displayed analgesic effect in MIA mice models of OA. Mice knee joints were intra-articularly (IA) injected with 0.75 mg of MIA or saline on day 1. For the short-term study (a,b), treatments (liraglutide, dexamethasone, or vehicle) were injected IA on day 3 and inflammation pain sensitivity was determined by the von Frey test on day 2 (for randomization), 7, and 10 (n = 15–19 per group). For the long-term study (c), treatments were administered on days 8, 15, and 22, and von Frey tests were performed on day 7 (for randomization), 14, 21, and 28 (n = 9–10 per group). (a) Paw withdrawal threshold was assessed by von Frey filament stimulation on days 2, 7, and 10. (b) The efficacy rate of liraglutide in the MIA short-term study was analyzed using GraphPad Prism 9.0 and the EC₅₀ value was determined at day 10 from the von Frey calculated values. (c) Paw withdrawal threshold was assessed by von Frey filament stimulation on days 0, 7, 14, 21, and 28. Arrows indicate the treatment with IA administration. Statistical analysis: Mean ± SEM. Mann–Whitney test with sequential strategy, **p < 0.01, ***p < 0.001, ****p < 0.0001 versus MIA control.