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. 2022 Jan 28;7:9. doi: 10.1038/s41525-021-00277-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — a Western blot showing significantly increased TIMMDC1 protein level in SSO1 and SSO2 treated affected (III-2 and III-6; lanes 1, 2 and 4, 5) compared to almost non-existent protein in the NC5 control treated (lanes 3, 6; very low-level signal was detectable after longer exposure) fibroblasts. Note that TIMMDC1 protein level was also increased in SSO1 and SSO2 treated parent (lanes 7, 8 and 10, 11) (heterozygous for the variant) compared to NC5 control (lanes 9 and 12) parent fibroblasts. However, as shown in b, no difference in the TIMMDC1 protein levels was observed in SSO1, SSO2 or NC5 control treated healthy unrelated individual’s fibroblasts (lanes 7, 8). Housekeeping protein β-tubulin was used as a loading control.