Table 2.

Overview of study procedures

	Visit 1 start	Visit 2 1 week	Visit 3 1 year	Visit 4 2 years	Visit 5 3 years
Visit to outpatient clinic	✔	–	✔	✔	✔
History and current status	✔	–	✔	✔	✔
Physical examination	✔	–	✔	✔	✔
Electrocardiogram	✔	–	✔	✔	✔
Echocardiogram	✔	–	✔	✔	✔
Holter monitoring	✔	–	✔	✔	✔
Ergometry	✔	–	✔	✔	✔
Signal-averaged ECG	✔	–	–	–	✔
CMR	✔	–	–	–	✔
Blood analysis	✔	✔a	✔a	✔a	✔

Note: Subjects undergo several investigations as summarised in this table. They are requested to visit the outpatient clinic at baseline and at 1‑year intervals thereafter. Subjects randomised to eplerenone visit the outpatient clinic or their general practitioner after 1 week to check serum potassium and eGRF, which are also checked in these subjects at the yearly visits. Of note, all investigations except blood analysis are already performed as part of routine clinical care, which routinely includes evaluation of signs and symptoms of DCM and ACM. For the purpose of the study, we collect and use these available data.

ECG electrocardiography, CMR cardiac magnetic resonance, eGFR estimated glomerular filtration rate, DCM dilated cardiomyopathy, ACM arrhythmogenic cardiomyopathy

^a only for subjects randomised to eplerenone