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Basic features of cGAS structure and ligand binding dynamics. (A) Schematic diagram of human cGAS functional domains; (B) Left, the crystal structure of ligand-free apo human-cGAS (“side view,” PDB ID: 4MKP). Right, the crystal structure of ligand-free human-cGAS dimer (“upright view,” PDB ID: 4LEY); (C) Globular catalytic domain of human cGAS in complex with dsDNA, ATP, and GTP (PDB ID: 4KB6). PDB: Protein data bank; aa: amino acids.
