Fig. 1.

The expression level of DOK family gene in cancer tissues and adjacent normal tissues. (A) The box plot shows the distribution of DOK family gene expression in all 33 cancer types. (B) The expression level of DOK family gene in cancer obtained from the GCSALite. (C) The heat map shows the difference in DOK expression between the primary tumor and adjacent normal tissues based on log2(fold change), for >5 adjacent normal samples of 18 cancer types. (D-J) Expression levels of DOK family gene in cancerous and adjacent normal tissues for all 18 cancer types. Boxplots represent the distribution of the DOK expression levels in primary tumor and normal tissues (if available) of different cancer types for each of the DOK. The band inside the box is the median expression values for the gene. (K) Association of DOK family gene expression with patient overall survival for different cancer types. The forest plots with the hazard ratios and 95% confidence intervals for overall survival for different cancer types to show survival advantage and disadvantage with increased gene expression of DOK family gene. Univariate Cox proportional hazard regression models were used for the association tests. ∗ P < 0.05; **P < 0.01; ***P < 0.001.