Fig. 4.

The correlation of DOK family gene expression with tumor microenvironment and immune infiltration. (A–C) The correlation matrix plots to shows the correlation between DOK family gene expression based on the ESTIMATE algorithm and the immune score, estimated score, and stromal score of 33 different cancer types. Spearman correlation is used for testing. The size of the dot represents the absolute value of the correlation coefficients. The larger the size, the higher the correlation (the higher the absolute correlation coefficient). This also applies to Fig. 6A–B. (D–F) The correlation between DOK1, DOK2, and DOK3 expression and immune infiltration levels in 32 cancers of TIMER. Red, positive correlation (P < 0.05); Blue, negative correlation (P < 0.05); Gray, not significant (P > 0.05).