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. 2021 Jun 12;36:73–87. doi: 10.1016/j.jare.2021.06.008

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© 2021 The Authors. Published by Elsevier B.V. on behalf of Cairo University.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 6 — Association of DOK family gene expression with tumor stemness, drug sensitivity, and signaling pathways. (A–B) Based on the Spearman correlation test, the correlation matrix between DOK family gene expression and cancer severity is RNAss (A) and DNAss (B). (C) Scatter plots to show the association between DOK family gene expression and drug sensitivity (Z-score from CellMiner interface) tested with Pearson Correlation using NCI-60 cell line data. (D) DOK family gene are associated with the activation and inhibition of 10 cancer pathways. The pie chart shows the correlation between DOK family gene and cancer pathways. Solid line indicates activation and dashed line indicates inhibition. (E) Correlation plot based on Spearman correlation test results, showing the correlation of gene expression among DOK family gene in all 33 cancer types. (F) Correlation analysis between DOK2 and DOK3 in GEPIA. (G) Correlation analysis between DOK1 and DOK2 in GEPIA. (H) Correlation analysis between DOK1 and DOK3 in GEPIA.