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Mechanism study of compound 36l. (A) Cellular thermal shift assays of PDEδ. 2 (50 μmol/L) and 36l (20 and 50 μmol/L) were incubated with Mia PaCa-2 cells for 2 h. The results were shown with melt curves. (B) Co-IP assay of compound 36l. Immunoprecipitation antibody: KRAS and control rabbit IgG; Western blotting antibody: PDEδ. Statistical difference was indicated by gray intensity analysis. Data were represented as means ± SEM, n = 3. ∗∗∗P < 0.001.
