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. 2021 Jun 2;12(1):107–134. doi: 10.1016/j.apsb.2021.05.031

Figure 13.

Figure 13

Anticancer immune response induced by OSPS. (A) OSPS-mediated tumor inhibition and lung metastasis. (B) Growth curves of primary tumors in 4T1 tumor-bearing mice. (C) Growth curves of distant tumors in 4T1 tumor-bearing mice. (D) H&E staining of lung metastasis in 4T1 tumor-bearing mice. (E) Number of metastatic nodules in 4T1 tumor-bearing mice (F) The Kyn/Trp ratio in primary tumors in 4T1 tumor-bearing mice. (G) Population of CD3+CD8+ T cells in distant tumors. (H) IFN-γ producing T-cells in distant tumors. (I) Treg cells in distant tumors. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, n = 5. CSPN, nanoparticles without NLG919. Reprinted with the permission from Ref. 218. Copyright © 2019 John Wiley and Sons Group.