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. 2021 Jun 2;12(1):107–134. doi: 10.1016/j.apsb.2021.05.031

Figure 2.

Figure 2

Cancer-immunity cycle. (1) Release of tumor antigens from damaged or dying cancer cells; (2) uptake and presentation of tumor antigens by APCs; (3) priming and activation of CD4+ and CD8+ T cells to trigger anticancer humoral and cellular immunity; (4) trafficking of NK cells, tumor antigen-specific antibodies, and CD8+ T cells; (5) infiltration and enrichment of NK cells, tumor antigen-specific antibodies, and CD8+ T cells into cancer tissues; (6) recognition and eradication of cancer cells via the cytotoxicity of CD8+ T cells and antibody-dependent cell-mediated cytotoxicity (ADCC) mediated by NK cells. The design of Fig. 2 was inspired by Fig. 1 of Ref. 20 with the copyright permission. Copyright © 2013 Elsevier Inc.