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. 2021 Jun 2;12(1):107–134. doi: 10.1016/j.apsb.2021.05.031

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© 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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A dual immunotherapy nanoparticle targeting PD-1 and OX40 improved anticancer immunity. (A) Schematic of DINP-facilitated enhancement of combination immunotherapy. (B) images of nanoparticles before and after antibody conjugation (scale bar: 100 nm). (C) tumor size and survival curves of C57BL/6 mice with B16F10 tumors following treatment with different drugs. (D) immunofluorescent images of tumors after treatment of different drugs. Reprinted with the permission from Ref. 123. Copyright © 2018 WILEY-VCH Publishing Group.