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Working model: HIRI exhibited diurnal variation which is related to the changes of gut microbiota. Gut microbiota produced and accumulated 3,4-DHPPA at ZT0. 3,4-DHPPA could inhibit the pro-inflammatory activity of macrophages and improve hepatic ischemia–reperfusion injury of mice by reducing the level of HDAC phosphorylation and inhibiting the activity of HDAC.
