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. 2021 Jul 17;12(1):308–315. doi: 10.1016/j.apsb.2021.07.007

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© 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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In vitro [¹⁸F] MAGL-4-11 autoradiography and distribution of MAGL with liver sections of human fibrotic patients. (A) Representative autoradiographic [¹⁸F] MAGL-4-11 images and double immunohistochemistry of MAGL (red) and α-SMA (green) in subjects with no, mild and severe fibrosis. (B) Radioactivity and MAGL fluorescence intensity in human liver sections. (C) Correlation between ex vivo liver uptake of [¹⁸F]MAGL-4-11 and liver MAGL expression in human liver sections, n = three human/group.