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. 2022 Jan 21;2022:3369858. doi: 10.1155/2022/3369858

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Copyright © 2022 Yongwen Luo et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Depletion of DTL suppresses BCa cell migration and invasion, attenuates the EMT of BCa cells, and inhibits the AKT/mTOR pathway. (a, b) Transwell migration and invasion assays in UMUC3 and T24 cells represented cell migration and invasion viability after depletion of DTL, and the migrated or invaded cell counts were statistically analyzed. (c) Western blotting analysis revealed the expression alterations of EMT markers and key proteins of the AKT/mTOR pathway after depletion of DTL. GAPDH was used as an internal control. (d, e) Wound healing assay represented cell migration viability after depletion of DTL, and the migrated cell counts were statistically analyzed. Statistical significance was assessed using two-tailed t-tests.