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. 2021 Jun 18;12(1):378–393. doi: 10.1016/j.apsb.2021.06.005

Figure 5.

Figure 5

Preparation and physicochemical characterization of FA-targeted co-formulation. (A) Formulation schematic. (B) The EE%, LC%, particle size and surface charge of targeted co-formulation. Data are presented as mean ± SD (n = 3). (C) TEM image of targeted co-formulation (scale bar = 100 nm). (D) The in vitro release of drugs from targeted co-formulation in 0.01 M PBS (pH = 5.5 and 7.4). Data are presented as mean ± SD (n = 4). (E) Particle size of targeted co-formulation following storage at 4 °C in aqueous solution. Data are presented as mean ± SD (n = 4). ∗P < 0.05 and ∗∗P < 0.01 relative to Day 0; NS, no significance. Non-targeted co-formulation also demonstrated similar physicochemical results observed by targeted counterpart.