Figure 8.

(A) Ex vivo distribution of NPs(Ce6) in organs and tumor for up to 48 h (n = 5); (B) Fluorescence signal intensity of NPs(Ce6) in tissues and tumors (n = 5); (C) Calculated distribution ratio TLR of NPs(Ce6) in the tumor to liver based on fluorescence intensities; (D) Tumor growth curves in mice bearing 4T1 tumor after treating with NPs(Ce6) with or without laser irradiation, red arrows indicated the time for injection of different formulations and blue for the time of laser administration (0.3 W/cm²). n = 7, data are expressed as mean ± SD, ∗P < 0.05 and ∗∗P < 0.01 versus the DOX and PBS groups. (E) Tumor growth inhibition by the combinational therapeutic treatment method comparing to the chemotherapeutic group on Day 21 after first treatment; (F) CD31 and TUNEL staining of tumors (scale bar: 50 μm).