Figure 4.

Antitumor efficacy of DM NGs on balb/c mice bearing 4T1 tumor. (A) The therapeutic schedule, deep penetration and long residence of DM NGs in vivo study. (B) Individual tumor growth curves and (C) average tumor growth curves after different treatments. (D) Average tumor weight after 11 days of treatment in various groups. (E) Survival curves of model mice (n = 8). (F) H&E (upper panel), Ki67 (middle panel) and TUNEL staining (lower panel) of tumor tissues after various treatments for 11 days. (G) Quantification of Ki67 proliferative cells ratio in panel. (H) The corresponding tumor apoptosis index. Data are presented as mean ± SD (n = 5). ∗P < 0.05; ∗∗P < 0.01; ∗∗∗P < 0.001.