Table 1.
Main types of CD45+immunecells resided in intestinal epithelium and lamina propria of WT and D6KO mice
| Celltype | WT (3760 cells) | D6K (3660 cells) | WT (%) | D6KO (%) | Deviation | Odds ratio | pValue | Assessmenta |
|---|---|---|---|---|---|---|---|---|
| Tgd | 3176 | 3132 | 84.47% | 85.57% | 1.11% | 0.92 | 0.1825 | ↑ |
| CD8+T cell | 124 | 108 | 3.30% | 2.95% | −0.35% | 1.12 | 0.4235 | ↓ |
| Macrophage | 93 | 102 | 2.47% | 2.79% | 0.31% | 0.88 | 0.4249 | ↑ |
| DC | 121 | 73 | 3.22% | 1.99% | −1.22% | 1.63 | 0.0010 | ↓↓ |
| B cell | 96 | 82 | 2.55% | 2.24% | −0.31% | 1.14 | 0.4042 | ↓ |
| NKT | 20 | 62 | 0.53% | 1.69% | 1.16% | 0.31 | 0.0000 | ↑↑ |
| NK cell | 40 | 24 | 1.06% | 0.66% | −0.41% | 1.63 | 0.0603 | ↓ |
| CD4+T cell | 24 | 31 | 0.64% | 0.85% | 0.21% | 0.75 | 0.3438 | ↑ |
| Treg | 19 | 21 | 0.51% | 0.57% | 0.07% | 0.88 | 0.7522 | = |
| ILC1 | 20 | 13 | 0.53% | 0.36% | −0.18% | 1.50 | 0.2966 | ↓ |
| ILC2 | 10 | 4 | 0.27% | 0.11% | −0.16% | 2.44 | 0.1797 | ↓ |
| Monocyte | 6 | 7 | 0.16% | 0.19% | 0.03% | 0.83 | 0.7878 | = |
| ILC3 | 5 | 0 | 0.13% | 0.00% | −0.13% | INF | 0.0625 | ↓ |
| Other T cell | 2 | 0 | 0.05% | 0.00% | −0.05% | INF | 0.5000 | ND |
| Neutrophil | 2 | 0 | 0.05% | 0.00% | −0.05% | INF | 0.5000 | ND |
| Mast cell | 1 | 1 | 0.03% | 0.03% | 0.00% | 0.97 | 1.0000 | ND |
| Basophil | 1 | 0 | 0.03% | 0.00% | −0.03% | INF | 1.0000 | ND |
D6KO, Dusp6 knockout; INF, infinite; ND, not determined; WT, wild-type.
a
Assessment rules: ND, not determined due to insufficiency of sample size (total counts <5) that could be resulted from low isolation rate and/or identification limitation; =, no difference reflected by a value of Deviation between −0.1 and 0.1%; ↑, a trend of increase with no statistical significance; ↓, a trend of decrease with no statistical significance; ↑↑, significant increase; ↓↓, significant decrease.