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(A) The cell-free PI3Kγ inhibitory activities of 49 hits and two positive inhibitors, IPI-145 and LY294002; (B) the anti-proliferation effects towards multiple tumor cells of 49 hits and two positive inhibitors, IPI-145 and LY294002; (C) the anti-proliferation effects towards multiple tumor cells of JN-KI3 and IPI-145; (D) the anti-proliferation effects towards multiple malignant tumor cells of JN-KI3 with the gradient of concentrations.
