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. 2021 Apr 20;36:1–13. doi: 10.1016/j.jare.2021.04.007

Fig. 4.

Fig. 4

JN-KI3 inhibited PI3K/AKT signaling pathway and induced apoptosis of (A) K562 and (B) RPMI-8226 cell lines at different concentrations from 0 to 20 μM after 24 h incubation. JN-KI3 inhibited PI3K/AKT signaling pathway and induced apoptosis of (C) K562 and (D) RPMI-8226 cell lines at different times from 0 to 24 h for 20 μM concentration. JN-KI3 induced apoptosis of hematologic malignancies illustrating by flow cytometry. Apoptosis of (E) K562 and (F) RPMI-8226 cell lines treated with different concentrations of JN-KI3 (from 0 μM to 10 μM) for 24 h.