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. 2021 Dec 16;21(2):100187. doi: 10.1016/j.mcpro.2021.100187

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 5 — Enriched proteins that exhibit continuous changes as identified by IPA in ADR-resistant and IMA-resistant cells.A, in the ADR-resistant cells, the three most significantly changed pathways were enriched by IPA from four DIA software. B, in the IMA-resistant cells, the three most significantly changed pathways were enriched by IPA from four DIA software. C, the heatmap shows the proteins (adjusted p value < 0.05 calculated by ANOVA) involved in sirtuin signaling pathway from four DIA software expression in the IMA-resistant and ADR-resistant cells, with the overlapped quantified proteins being highlighted in red. Each row indicats a protein, and each column indicats a sample. The protein intensity matrix was normalized by Z-score and colored in the heatmap. D, Venn diagram shows the 16 overlapped proteins involved in the sirtuin signaling pathway in the ADR-resistant cells. E, Venn diagram shows the five overlapped proteins involved in the sirtuin signaling pathway in the IMA-resistant cells. ADR, adriamycin; DIA, data-independent acquisition; IMA, imatinib; IPA, ingenuity pathway analysis.