Table 1.
IC50 values and resistance index of the derivative K562 cells
| Model | IC50 (μM, 95% confidence interval)a |
Resistance indexb | |
|---|---|---|---|
| IMA | ADR | ||
| Native K562 cells | 0.37 (0.26–0.54) | 0.29 (0.24–0.35) | 1 |
| Model IMA phase 1 | 0.74 (0.61–0.90) | — | 2 |
| Model IMA phase 2 | 1.29 (1.06–1.58) | — | 3.49 |
| Model IMA phase 3 | 4.29 (3.03–6.36) | — | 11.59 |
| Model ADR phase 1 | — | 0.80 (0.51–1.24) | 2.76 |
| Model ADR phase 2 | — | 1.86 (1.5–2.30) | 6.41 |
| Model ADR phase 3 | — | 2.05 (1.32–3.32) | 7.06 |
a
IC50 values represent the best-fit values and 95% confidence interval of three independent experiments performed.
b
Resistance index was calculated by dividing the best-fit IC50 values of native K562 cells in response to ADR and IMA to the best-fit IC50 values of model cells.