Table 3.
IC50 values and reverse index of the derivative resistant K562 cells
| Drugs | IC50 (μM, 95% confidence interval)a |
Resistance indexb | Reversal indexc | ||
|---|---|---|---|---|---|
| Native K562 | Model IMA | Model ADR | |||
| IMA | 0.26 (0.19–0.36) | 1.55 (1.12–2.19) | — | 5.96 | 1 |
| IMA + AGI-6780 (2 μM) | 0.35 (0.26–0.48) | 1.09 (0.80–1.49) | — | 3.11 | 1.92 |
| IMA + AGI-6780 (4 μM) | 0.26 (0.20–0.33) | 0.53 (0.27–1.16) | — | 2.03 | 2.94 |
| ADR | 0.37 (0.31–0.45) | — | 0.67 (0.49–0.95) | 1.81 | 1 |
| ADR + AGI-6780 (2 μM) | 0.38 (0.31–0.46) | — | 0.43 (0.27–0.68) | 1.13 | 1.60 |
| ADR + AGI-6780 (4 μM) | 0.44 (0.31–0.61) | — | 0.29 (0.18–0.47) | 0.66 | 2.74 |
a
IC50 values represent the best-fit values, and 95% confidence interval of three independent experiments were performed.
b
Resistance index was calculated by dividing the best-fit IC50 values of parental K562 cells to ADR or IMA by the best-fit IC50 values of the model cells.
c
Reversal index was calculated by dividing the resistance index in the absence of ACI-6780 by the resistance index in the presence of AGI-6780.