Table 2. Cohort and Case-control studies clinical outcomes.

NS = Not Specified; IRR = Incidence Rate Ratio

Author	Clinical manifestations	Other reported adverse effects	Outcome (Incidence, IRR)
Degner et al. [10]	None	Hepatic (elevated transaminases), Cardiovascular, dermatological (cutaneous edema), restless legs, subclinical pancreatitis	0%, NS
Jung et al. [11]	None	NS	0%, NS
Grover et al. [12]	NS	NS	80%, NS
Leth-Møller et al. [13]	NS	NS	3.84%, 1.12 [1.05-1.19]