Table 1.
Characteristics of the included studies
| References | Animal, sex | Anesthetic | Method of SAH | MSCs source | Type of MSCs derived therapy | Time of administration | Tre(n)/con(n) | Assessment time | Outcome measure |
|---|---|---|---|---|---|---|---|---|---|
| Chen [21] | SD rat, male | Pentobarbital, IP | Autogenous blood | Human UC-MSCs | UC-MSCs, 2 × 105, ICV | − 1, 10 days post SAH | 16/16 | 21 days | Garcia score and beam balance test (higher is better) |
| Gao [22] | SD rat, male | Chloral hydrate, IP | Endovascular perforation | BM-MSCs | BM-MSCs-derived EVs, 100 ug, IV | 1 h post SAH | 12/12; 6/6 | 48 h | Garcia score (higher is better); BWC (lower is better) |
| Han [12] | SD rat, male | Isoflurane, inhalation | Endovascular perforation | Rat BM-MSCs | BM-MSCs-derived EVs, 100 ug/500 ul, IV | 10 min post SAH | 5/5; 5/5 | 48 h | Garcia score (higher is better); BWC (lower is better) |
| Lai [14] | C57BL/6 mice, male | Chloral hydrate, IP | Autogenous blood | Mice BM-MSCs | BM-MSCs-derived EVs, IV | 22 h post SAH | 18/18; 6/6 | 24 h | Garcia score (higher is better); BWC (lower is better) |
| Liu [23] | SD rat, male | Pentobarbital, IP | Endovascular perforation | Rat BM-MSCs | BM-MSCs, 3 × 106, IV | 1 h post SAH | 12/12; 6/6 | 72 h | Garcia score (higher is better); BWC (lower is better) |
| Liu [24] | SD rat, NR | NR | Autogenous blood | Human UC-MSCs | UC-MSCs-derived EVs, 100 ug/ml, IV | NR | 6/6; 6/6 | 24 h | Behavior score (lower is better); BWC (lower is better) |
| Nijboer [13] | Wistar rat, male | Isoflurane, inhalation | Endovascular perforation | SD rat BM-MSCs | BM-MSCs, 1.5 × 106, IN | 6 days post SAH | 13/10 | 21 days | Adhesive removal task (lower is better) |
| Xiong [25] | SD rat, male | Isoflurane, inhalation | Endovascular perforation | Rat BM-MSCs | BM-MSCs-derived EVs, 200 ug/200 ul, IV | 1 h post SAH | 5/5; 5/5 | 24 h | Garcia score (higher is better); BWC (lower is better) |
| Zhao [26] | SD rat, male | Pentobarbital, IP | Autogenous blood | Human UC-MSC | UC-MSCs-derived EVs, 400 ug/200 ul, IV | 1 h post SAH | 5/5; 5/5 | 24 h | Garcia score (higher is better); BWC (lower is better) |
SAH subarachnoid hemorrhage, MSCs mesenchymal stem cells, Tre treatment, Con control, IP intraperitoneal, NR not recorded, UC-MSCs umbilical cord mesenchymal stem cells, BM-MSCs bone marrow mesenchymal stem cells, EVs extracellular vesicles, ICV intracerebroventricular, IV intravenous, IN intranasal, BWC brain water content