Table 4.
Stratified meta-analysis of heterogeneity on brain water content
| Categories | No. of studies | Pooled SMD (95% CI) | p value | Heterogeneity test | Between groups p value | ||
|---|---|---|---|---|---|---|---|
| Q statistics | I2 | p value | |||||
| Anesthetic type | 0.03 | ||||||
| Pentobarbital | 2 | − 1.82 (− 2.90, − 0.74) | 0.001 | 0.28 | 0% | 0.60 | |
| Chloral hydrate | 2 | − 1.07 (− 2.17, 0.03) | 0.06 | 1.47 | 32% | 0.22 | |
| Isoflurane | 2 | − 3.03 (− 4.52, − 1.54) | < 0.0001 | 0.01 | 0% | 0.92 | |
| NR | 1 | − 4.68 (− 7.23, − 2.13) | 0.0003 | NA | NA | NA | |
| Method of SAH | 0.88 | ||||||
| Autogenous blood | 3 | − 2.24 (− 4.39, − 0.09) | 0.04 | 9 | 78% | 0.01 | |
| Endovascular perforation | 4 | − 2.06 (− 2.88, − 1.24) | < 0.00001 | 2.35 | 0% | 0.50 | |
| MSCs species | 0.52 | ||||||
| Non-xenogeneic | 4 | − 1.81 (− 3.00, − 0.62) | 0.003 | 6.50 | 54% | 0.09 | |
| Xenogeneic | 2 | − 3.25 (− 5.67, − 0.84) | 0.008 | 2.49 | 60% | 0.11 | |
| NR | 1 | − 1.70 (− 3.11, − 0.30) | 0.02 | NA | NA | NA | |
| MSCs type | 0.24 | ||||||
| UC-MSCs | 2 | − 3.25 (− 5.67, − 0.84) | 0.008 | 2.49 | 60% | 0.11 | |
| BM-MSCs | 5 | − 1.72 (− 2.60, − 0.83) | 0.0002 | 6.55 | 39% | 0.16 | |
| Therapy type | 0.46 | ||||||
| MSCs | 1 | − 1.59 (− 2.96, − 0.22) | 0.02 | NA | NA | NA | |
| MSCs-derived EV or exosome | 6 | − 2.26 (− 3.36, − 1.15) | < 0.0001 | 11.95 | 58% | 0.04 | |
SMD standardized mean difference, CI confidence interval, SAH subarachnoid hemorrhage, MSCs mesenchymal stem cells, NR not recorded, UC-MSCs umbilical cord mesenchymal stem cells, BM-MSCs bone marrow mesenchymal stem cells, EVs extracellular vesicles, NA not available