Fig. 5.

Functions of fluoxetine in A1 astrocyte reactivity are independent of classical G protein pathways. A, B Effects of the inhibitor of Gq protein, YM-254890 on the mRNA levels of A1-special markers in astrocytes with or without fluoxetine treatment after A1 (A) or IL-6 (B) stimulation. Quantitative data are mean ± s.e. Data were analyzed using two-way ANOVA, then combined with Tukey’s multiple comparison to assess the differences between groups. All data represent the results of three independent experiments. **P < 0.01, and ***P < 0.001 vs respective Control cells treated with PBS; ^##P < 0.01, and ^###P < 0.001 vs Control cells treated with A1 (A) or IL-6 (B) stimulation