Table 3.
Outcome of linear regression analysis on five cognitive domains as dependent variable and the SA constructs as predictors and age, sex and years of education as correlates
| Domain | All three components combined Beta (95% CI), p value |
Component I, Absence of disease Beta (95% CI), p value |
Component II, High functioning Beta (95% CI), p value |
Component III, Active engagement Beta (95% CI), p value |
|---|---|---|---|---|
| Verbal function | ||||
| SA | − 0.19 (− 0.58, 0.20) | − 0.36 (− 0.74, 0.03) | − 0.37 (0.93, 0.19) | 0.13 (− 0.27, 0.53) |
| Age | 0.00 (− 0.03, 0.04) | 0.00 (− 0.03, 0.04) | 0.00 (− 0.03, 0.04) | 0.01 (− 0.03, 0.05) |
| Sex | 0.19 (− 0.21, 0.59) | 0.18 (− 0.21, 0.57) | 0.17 (− 0.22, 0.57) | 0.22 (− 0.17, 0.62) |
| Education | 0.25 (0.17, 0.33)*** | 0.26 (0.18, 0.33)*** | 0.27 (0.18, 0.34)*** | 0.26 (0.18, 0.33)*** |
| Visuospatial | ||||
| SA | − 0.06 (− 0.58, 0.47) | 0.02 (− 0.51, 0.55) | 0.04 (− 0.71, 0.79) | 0.08 (− 0.46, 0.61) |
| Age | − 0.01 (− 0.07, 0.04) | − 0.01 (− 0.06, 0.04) | − 0.01 (− 0.06, 0.04) | − 0.01 (− 0.06, 0.04) |
| Sex | 0.45 (− 0.09, 0.98) | 0.46 (− 0.08, 0.99) | 0.46 (− 0.08, 1.00) | 0.46 (− 0.07, 0.99) |
| Education | − 0.05 (− 0.16, 0.05) | − 0.05 (− 0.16, 0.05) | − 0.05 (− 0.16, 0.05) | − 0.05 (− 0.16, 0.05) |
| Processing speed | ||||
| SA | 0.35 (0.00, 0.70) | 0.39 (0.05, 0.74)* | 0.43 (− 0.07, 0.93) | 0.11 (− 0.25, 0.47) |
| Age | − 0.05 (− 0.08, − 0.01)** | − 0.05 (− 0.08, − 0.02)** | − 0.05 (− 0.08, − 0.02)** | − 0.06 (− 0.09, − 0.02)** |
| Sex | − 0.67 (− 1.02, − 0.31)*** | − 0.68 (− 1.03, − 0.34)*** | − 0.67 (− 1.03, − 0.32)*** | − 0.72 (− 1.08, − 0.36)*** |
| Education | 0.02 (− 0.05, 0.09) | 0.02 (− 0.05, 0.09) | 0.01 (− 0.06, 0.08) | 0.02 (− 0.05, 0.09) |
| Episodic memory | ||||
| SA | 0.04 (− 0.37, 0.46) | − 0.23 (− 0.64, 0.19) | 0.17 (− 0.43, 0.76) | 0.21 (− 0.21, 0.63) |
| Age | − 0.03 (− 0.07, 0.02) | − 0.03 (− 0.07, − 0.01) | − 0.02 (− 0.06, − 0.02) | − 0.02 (− 0.06, 0.01) |
| Sex | − 0.48 (− 0.90, − 0.05)* | − 0.51 (− 0.93, − 0.09)* | − 0.47 (− 0.89, − 0.04)* | − 0.47 (− 0.89, − 0.06)* |
| Education | 0.03 (− 0.05, 0.12) | 0.03 (− 0.05, 0.12) | 0.03 (− 0.05, 0.11) | 0.03 (− 0.05, 0.12) |
| Working memory | ||||
| SA | 0.28 (− 0.11, 0.67) | 0.40 (0.02, 0.79)* | 0.22 (− 0.35, − 0.78) | 0.15 (− 0.26, 0.55) |
| Age | − 0.00 (− 0.04, 0.04) | − 0.00 (− 0.04, 0.04) | − 0.01 (− 0.04, 0.03) | − 0.01 (− 0.05, 0.03) |
| Sex | 0.24 (− 0.16, 0.64) | 0.24 (− 0.16, 0.62) | 0.22 (− 0.19, 0.62) | 0.20 (− 0.20, 0.60) |
| Education | 0.09 (0.01, 0.17)* | 0.09 (0.01, 0.16)* | 0.08 (− 0.00, 0.16) | 0.08 (0.00, 0.16)* |
Significant effects (p < 0.05), 95% CI and beta weights are presented in bold type. *p < 0.05; **p < 0.01; ***p < 0.001