Fig. 1.

Eriodictyol ameliorates cognitive deficits in APP/PS1 mice, as measured using the Morris water maze. A The chemical structure of eriodictyol. B Animal grouping and experimental scheme for the effect of eriodictyol on memory deficits in APP/PS1 mice. C Escape latency of mice during the fifth day of platform trials. D The percentage of distance traveled in target quadrant. E The time spent in the target quadrant and F the number of platform crossings in the probe trials were determined. G The swimming speed of mice in the Morris water maze. H The track of the mouse in the Morris water maze was also recorded. I The body weight of each mouse was recorded during drug administration. The dose of eriodictyol was 50 mg/kg, and the mice were intraperitoneally injected three times a week for 3 months. Data are presented as means ± SD, n = 6. *P < 0.05, **P < 0.01 and ***P < 0.001 compared with the APP/PS1-control group