Table 1.
Active ingredient list of HDHs in the treatment of coronavirus infection.
| MOL ID | Ingredient | Classification | Chem 2D | Core target |
|---|---|---|---|---|
| MOL000098 | Quercetin | Flavonoid |
|
IL6, EGFR, CASP3, RELA, PTGS2, PPARG, NOS3 |
| MOL000006 | Luteolin | Flavonoid |
|
IL6, EGFR, CASP3, RELA, PTGS2, PPARG, |
| MOL000173 | Wogonin | Flavonoid |
|
IL6, CASP3, MAPK14, RELA, PTGS2, PPARG, LCK |
| MOL000422 | Kaempferol | Flavonoid |
|
CASP3, MAPK8, RELA, PTGS2, PPARG, NOS3 |
| MOL008228 | Andrographin | Flavonoid |
|
PTGS2, NOS3 |
| MOL003095 | 5-hydroxy-7-methoxy-2-(3,4,5-trimethoxyphenyl)chromone | Flavonoid |
|
MAPK14, PTGS2, PPARG, NOS3, LCK |
| MOL001689 | Acacetin | Flavonoid |
|
CASP3, RELA, PTGS2, LCK |
| MOL008239 | Quercetin tetramethyl(3′,4′,5,7) ether | Flavonoid |
|
MAPK14, PTGS2, PPARG, NOS3 |
| MOL008204 | Mono-O-methylwightin | Flavonoid |
|
MAPK14, PTGS2, PPARG, NOS3 |
| MOL008209 | Deoxycamptothecine | Alkaloid |
|
MAPK14, PTGS2, PPARG, NOS3 |
| MOL003283 | (2R,3R,4S)-4-(4-hydroxy-3-methoxy-phenyl)-7-methoxy-2,3-dimethylol-tetralin-6-ol (Isolariciresinol) | Lignans |
|
MAPK14, PTGS2, PPARG, NOS3 |
| MOL002928 | Oroxylin a | Flavonoid |
|
IL6, CASP3, PTGS2, LCK |
| MOL002309 | Indirubin | Alkaloid |
|
MAPK14, PTGS2, PPARG, NOS3 |
| MOL008206 | Moslosooflavone | Flavonoid |
|
MAPK14, PTGS2, PPARG, LCK |
| MOL008230 | Andrographidine F | Flavonoid |
|
MAPK14, PTGS2, PPARG |
| MOL000358 | β-sitosterol | Steroid |
|
CASP3, NFKB1, PTGS2 |
| MOL001551 | Betulin | Terpenoid |
|
MAPK3, MAPK1, NFKB1 |