Fig. 2.

Randomisation and functional analysis procedure. A Schematic representing the structure of annotated TADs. B Null dataset one: random TADs. TADs were randomised within the same chromosome by selecting regions of equal size to the original TAD which also contain the same number of genes, thus controlling for the effect of the linear genome. C Null dataset two: random genome TADs. In order to remove the effect of the linear genome another null TAD set was generated in which the TADs remained in the same positions but the order of genes on the chromosome were randomised. D Pairwise strategy for comparing functional similarity between genes in the same TAD. All possible pairs of genes in each TAD were compared